Older TNF Inhibitors Better for Psoriatic Arthritis… meta-anlaysis suggests that older TNF-inhibitors may be preferable to newer agents after first-line DMARD therapy has failed in psoriatric arthritis.
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The Difficulty of Diagnosis Ankylosing…An overview of a survey that highlights the problems associated with diagnosing Ankylosing Spondylitis, which leads to poor quality of life.
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Severe apoptotic enteropathy caused by methotrexate treatment for rheumatoid arthritis.Related Articles
Severe apoptotic enteropathy caused by methotrexate treatment for rheumatoid arthritis.
Joint Bone Spine. 2015 Oct 19;
Authors: Toquet S, Nguyen Y, Sabbagh A, Djerada Z, Boulagnon C, Bani-Sadr F
Abstract
The folic acid antagonist methotrexate is a cornerstone treatment of rheumatoid arthritis. Its use is limited chiefly by gastrointestinal toxicity, which is among the main reasons for methotrexate discontinuation. Here, we report the case of a 40-year-old man on chronic methotrexate therapy in whom life-threatening apoptotic enteropathy with watery diarrhea and hypovolemic shock developed after he was switched from the oral to the intramuscular route, with no change in dosage. Colonic biopsies suggested drug-induced colitis, showing a nonspecific, mildly inflammatory infiltrate of lymphocytes and plasma cells, dilated damaged crypts, and a marked increase in basal crypt apoptosis (>20 apoptotic bodies/100 crypts). See Original Article
Severe apoptotic enteropathy caused by methotrexate treatment for rheumatoid arthritis.
Joint Bone Spine. 2015 Oct 19;
Authors: Toquet S, Nguyen Y, Sabbagh A, Djerada Z, Boulagnon C, Bani-Sadr F
Abstract
The folic acid antagonist methotrexate is a cornerstone treatment of rheumatoid arthritis. Its use is limited chiefly by gastrointestinal toxicity, which is among the main reasons for methotrexate discontinuation. Here, we report the case of a 40-year-old man on chronic methotrexate therapy in whom life-threatening apoptotic enteropathy with watery diarrhea and hypovolemic shock developed after he was switched from the oral to the intramuscular route, with no change in dosage. Colonic biopsies suggested drug-induced colitis, showing a nonspecific, mildly inflammatory infiltrate of lymphocytes and plasma cells, dilated damaged crypts, and a marked increase in basal crypt apoptosis (>20 apoptotic bodies/100 crypts). See Original Article
Older TNF Inhibitors Better for Psoriatic Arthritis
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